2-Chloropyrimidine → HCID 178511661, compound

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of trans-1,4-cyclohexanediamine (1.50 g, 13.1 mmol) and 2-chloropyrimidine (500 mg, 4.37 mmol) was heated at 160° C. for 2 h then cooled to RT. The mixture was diluted with water, filtered, and the aqueous phase was extracted three times with ethyl acetate. The combined organic extracts were dried over sodium sulfate and concentrated to afford 22A (235 mg, 28%). MS (ES): m/z=193 [M+H]+.

Provenance & Evidence