3-Amino-4-chlorobenzonitrile → 2-Chloro-5-cyanobenzene-1-sulfonyl chloride

HRID 1631520Notes

Reaction equation

HRID 1631520 reaction equation
FC1C=CC([S:8]([Cl:11])(=[O:10])=[O:9])=CC=1OC.N[C:15]1[CH:16]=[C:17]([CH:20]=[CH:21][C:22]=1[Cl:23])[C:18]#[N:19]>>[Cl:23][C:22]1[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][C:15]=1[S:8]([Cl:11])(=[O:10])=[O:9]

Participants

3

Reactant 2

HCID 1044643-Amino-4-chlorobenzonitrileHCID 27834084-Fluoro-3-methoxybenzenesulfonyl chloride2×

Product 1

HCID 533019942-Chloro-5-cyanobenzene-1-sulfonyl chloride

Procedure

The titled compound is prepared analogously to 4-fluoro-3-methoxy-benzenesulfonyl chloride (Intermediate 102a) by replacing 4-fluoro-3-methoxyaniline with 3-amino-4-chloro-benzonitrile.

Sources & evidence

ORD record
ord-f6abd837140649b68d3bcf61b4fb5019
Source dataset
uspto-grants-2014_07
Patent number
US08791256B2

Reaction notes

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