4-Amino-2-fluorobenzotrifluoride → 3-Fluoro-4-(trifluoromethyl)benzene-1-sulfonyl chloride

HRID 1631530Notes

Reaction equation

HRID 1631530 reaction equation
FC1C=CC([S:8]([Cl:11])(=[O:10])=[O:9])=CC=1OC.[F:14][C:15]1[CH:16]=[C:17](N)[CH:18]=[CH:19][C:20]=1[C:21]([F:24])([F:23])[F:22]>>[F:14][C:15]1[CH:16]=[C:17]([S:8]([Cl:11])(=[O:10])=[O:9])[CH:18]=[CH:19][C:20]=1[C:21]([F:24])([F:23])[F:22]

Participants

3

Reactant 2

HCID 27359144-Amino-2-fluorobenzotrifluorideHCID 27834084-Fluoro-3-methoxybenzenesulfonyl chloride2×

Product 1

HCID 866201533-Fluoro-4-(trifluoromethyl)benzene-1-sulfonyl chloride

Procedure

The titled compound is prepared analogously to 4-fluoro-3-methoxy-benzenesulfonyl chloride (Intermediate 102a) by replacing 4-fluoro-3-methoxyaniline with 3-fluoro-4-trifluoromethyl-phenylamine.

Sources & evidence

ORD record
ord-328b6e3dee9b40af8751e8ab313147bc
Source dataset
uspto-grants-2014_07
Patent number
US08791256B2

Reaction notes

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