HCID 45273621, compound → HCID 67218906, compound

HRID 1631537Notes

Reaction equation

HRID 1631537 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]2[C:15]3=[N:16][CH:17]=[CH:18][CH:19]=[C:14]3[C:13]([CH2:20][C:21]([OH:23])=[O:22])=[C:12]2[CH3:24])(=[O:10])=[O:9])=[CH:4][C:3]=1[C:25]#[N:26].[CH3:27]OC(=O)CC1C2C(=NC=CC=2)NC=1CC>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]2[C:15]3=[N:16][CH:17]=[CH:18][CH:19]=[C:14]3[C:13]([CH2:20][C:21]([OH:23])=[O:22])=[C:12]2[CH2:24][CH3:27])(=[O:9])=[O:10])=[CH:4][C:3]=1[C:25]#[N:26]

Participants

3

Reactant 2

HCID 45273621HCID 45273621, compoundHCID 67219373HCID 67219373, compound2×

Product 1

HCID 67218906HCID 67218906, compound

Procedure

The titled compound is prepared analogously to [1-(4-chloro-3-cyano-benzenesulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acid (Example 103) by replacing (2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-acetic acid methyl ester with (2-ethyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-acetic acid methyl ester (Intermediate 87c). (MH+ 404)

Sources & evidence

ORD record
ord-77fb9800e0f94d3aadce01a1a8870d85
Source dataset
uspto-grants-2014_07
Patent number
US08791256B2

Reaction notes

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