3-(Trifluoromethoxy)aniline → HCID 136352192, compound

HRID 1631592Notes

Reaction equation

HRID 1631592 reaction equation
[N:1]1([C:7]2[N:8]=[C:9]([CH2:14][C:15]([O-:17])=O)[NH:10][C:11](=[O:13])[CH:12]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Na+].[F:19][C:20]([F:30])([F:29])[O:21][C:22]1[CH:23]=[C:24]([CH:26]=[CH:27][CH:28]=1)[NH2:25]>>[N:1]1([C:7]2[N:8]=[C:9]([CH2:14][C:15]([NH:25][C:24]3[CH:26]=[CH:27][CH:28]=[C:22]([O:21][C:20]([F:19])([F:29])[F:30])[CH:23]=3)=[O:17])[NH:10][C:11](=[O:13])[CH:12]=2)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 737533-(Trifluoromethoxy)anilineHCID 136041844Sodium (4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate

Product 1

HCID 136352192HCID 136352192, compoundYield 60.3%

Procedure

The product is prepared according to the procedure described in Example 5, using 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 270 mg of 3-(trifluoromethoxy)aniline in place of the 2,4-difluoroaniline. 230 mg of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(trifluoromethoxy)phenyl]acetamide are obtained in the form of a white solid, the characteristics of which are the following:

Workup

  1. customThe product is prepared

Sources & evidence

ORD record
ord-bbdef2714401446e80299c3b6c058d5d
Source dataset
uspto-grants-2014_07
Patent number
US08791255B2

Reaction notes

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