3-(Propan-2-yloxy)aniline → HCID 136352193, compound

HRID 1631593Notes

Reaction equation

HRID 1631593 reaction equation
[N:1]1([C:7]2[N:8]=[C:9]([CH2:14][C:15]([O-:17])=O)[NH:10][C:11](=[O:13])[CH:12]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Na+].[CH:19]([O:22][C:23]1[CH:24]=[C:25]([CH:27]=[CH:28][CH:29]=1)[NH2:26])([CH3:21])[CH3:20]>>[N:1]1([C:7]2[N:8]=[C:9]([CH2:14][C:15]([NH:26][C:25]3[CH:27]=[CH:28][CH:29]=[C:23]([O:22][CH:19]([CH3:21])[CH3:20])[CH:24]=3)=[O:17])[NH:10][C:11](=[O:13])[CH:12]=2)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 5732203-(Propan-2-yloxy)anilineHCID 136041844Sodium (4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate

Product 1

HCID 136352193HCID 136352193, compoundYield 64%

Procedure

The product is prepared according to the procedure described in Example 5, using 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 572 mg of 3-isopropoxyaniline in place of the 2,4-difluoroaniline. 228 mg of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-[3-(propan-2-yloxy)phenyl]acetamide are obtained in the form of a white solid, the characteristics of which are the following:

Workup

  1. customThe product is prepared

Sources & evidence

ORD record
ord-92a345720c3747a491fae9d00d3f7da0
Source dataset
uspto-grants-2014_07
Patent number
US08791255B2

Reaction notes

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