1,2-Dichloroethane → 4-(5-bromo-2-chloropyrimidin-4-yl)-N-(1-(4-chlorophenyl)cyclopropyl)morpholine-3-carboxamide

Participants

Reaction Steps

The title compound was prepared in a manner similar to PREPARATION x31 using 4-(5-bromo-2-chloropyrimidin-4-yl)morpholine-3-carboxylic acid (PREPARATION x30, 0.244 g, 0.756 mmol), EDC (0.174 g, 0.908 mmol), HOBt (0.123 g, 0.908 mmol), N,N-diisopropylethylamine (0.138 mL, 0.794 mmol), and 1-(4-chlorophenyl)cyclopropanamine, HCl (0.185 g, 0.908 mmol) in THF (8 mL). ESI-MS m/z [M+H]+ calc'd for C18H17BrCl2N4O2, 470.99. found 471.3.

Provenance & Evidence