HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-methylbutan-2-ol → (R)-4-(2-chloro-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)-2-methylbutan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-methylbutan-2-ol | HCID 10607172 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Reactant | (R)-2-chloro-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine | HCID 86670088 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | (R)-4-(2-chloro-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)-2-methylbutan-2-ol | HCID 86670126 | — |
Reaction Steps
The title compound was prepared in a manner similar to PREPARATION x5 using (R)-2-chloro-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine (PREPARATION x2, 300 mg, 1.324 mmol) in DMSO (7 mL), sodium tert-butoxide (153 mg, 1.588 mmol) and 4-bromo-2-methylbutan-2-ol (243 mg, 1.456 mmol) (306 mg, 74%). ESI-MS m/z [M+H]+ calc'd for C14H21ClN4O2, 313.14. found 313.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791107B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-d388b852785d4e6aa872c87c3bd2d242 |
| Source note | uspto-grants-2014_07 |