HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 21698362, compound → (R)-2-chloro-5-((1-methyl-1H-pyrazol-4-yl)methyl)-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 21698362 | HCID 21698362 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Reactant | (R)-2-chloro-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine | HCID 86670088 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | (R)-2-chloro-5-((1-methyl-1H-pyrazol-4-yl)methyl)-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine | HCID 86670128 | — |
Reaction Steps
The title compound was prepared in a manner similar to PREPARATION x5 using (R)-2-chloro-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine (PREPARATION x2, 300 mg, 1.324 mmol) in DMSO (6 mL), sodium tert-butoxide (153 mg, 1.588 mmol) and 4-(chloromethyl)-1-methyl-1H-pyrazole (190 mg, 1.456 mmol) (113 mg, 26%). ESI-MS m/z [M+H]+ calc'd for C41H17ClN6O, 321.12. found 321.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791107B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-248e466008d146279f9287b823b1739a |
| Source note | uspto-grants-2014_07 |