HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Tosyl-1H-pyrrolo(2,3-B)pyridine-4-boronic acid pinacol ester → HCID 68194696, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Tosyl-1H-pyrrolo(2,3-B)pyridine-4-boronic acid pinacol ester | HCID 49758926 | — |
| Reactant | HCID 86670087 | HCID 86670087 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Solvent | Sodium Bicarbonate | HCID 516892 | — |
| Product | HCID 68194696 | HCID 68194696 | — |
Reaction Steps
The title compound was prepared in a manner similar to EXAMPLE 2 using 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine (PREPARATION x2, 527 mg, 1.324 mmol), 2-chloro-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine (150 mg, 0.662 mmol), and PdCl2(dppf) (38.7 mg, 0.053 mmol) in dioxane (3.5 mL) and aqueous saturated NaHCO3 (0.8 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791107B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-89c464bf20144de4b1898f20687938f7 |
| Source note | uspto-grants-2014_07 |