Water → HCID 68089123, compound

Participants

Reaction Steps

To a solution of the 4-[1-(4-benzyloxy-cyclohexyl)-meth-(E)-ylidene]-2-(2,4,6-trimethyl-phenyl)-cyclopentane-1,3-dione (4.0 g, 9.6 mmol) in dichloromethane (60 ml) and triethylamine (2 ml) is added the pivaloyl chloride (1.73 g, 14.3 mmol) at 0° C. The reaction is allowed to warm to room temperature and then stirred for 3 hours. The reaction mixture is poured into water (50 ml) and extracted with dichloromethane (2×50 ml). The combined organic extracts are dried over magnesium sulphate, filtered and evaporated to give 2,2-dimethyl-propionic acid 4-[1-(4-benzyloxy-cyclohexyl)-meth-(E)-ylidene]-3-oxo-2-(2,4,6-trimethyl-phenyl)-cyclopentyl ester (4.5 g).

Provenance & Evidence