HCID 68089123, compound → HCID 66867975, compound

Participants

Reaction Steps

The 2,2-dimethyl-propionic acid 4-[1-(4-benzyloxy-cyclohexyl)-meth-(E)-ylidene]-3-oxo-2-(2,4,6-trimethyl-phenyl)-cyclopentyl ester (4.5 g, 9.0 mmol) is dissolved in ethyl acetate (40 ml), 1 g of 5% palladium on carbon is added and the reaction mixture is placed under hydrogen pressure (3 bars) for 3 hours. The reaction mixture is filtered and washed with ethyl acetate. The filtrate is absorbed onto silica gel and purified by flash chromatography to give a sticky solid. The solid was crystallised from hexane to give 2,2-dimethyl-propionic acid 4-(4-hydroxy-cyclohexylmethyl)-3-oxo-2-(2,4,6-trimethyl-phenyl)-cyclopentyl ester (1.37 g).

Provenance & Evidence