Pyridine → HCID 86667787, compound

Participants

Reaction Steps

2,2-dimethyl-propionic acid 3-oxo-4-(4-oxo-cyclohexylmethyl)-2-(2,4,6-trimethyl-phenyl)-cyclopentyl ester (150 mg, 0.36 mmol) is dissolved in ethanol (8 ml) and hydroxylamine hydrochloride (36 mg, 0.43 mmol) is added. The solution is stirred while adding pyridine (32 mg, 0.40 mmol). The reaction mixture is heated to reflux for 2 hours. The reaction mixture is diluted with water and extracted with dichloromethane (1×40 ml). The organic extract is dried over magnesium sulphate, filtered and evaporated to a brown gum. The product is purified by HPLC to give 2,2-dimethyl-propionic acid 4-(4-methoxyimino-cyclohexylmethyl)-3-oxo-2-(2,4,6-trimethyl-phenyl)-cyclopentyl ester.

Provenance & Evidence