2-(4-bromo-2,6-dimethyl-phenyl)-4-[1-cyclohexyl-meth-(E)-ylidene]-cyclopentane-1,3-dione → 4-Cyclohexylmethyl-2-(2,6-dimethyl-phenyl)-cyclopentane-1,3-dione

Participants

Reaction Steps

To a solution of 2-(4-bromo-2,6-dimethyl-phenyl)-4-[1-cyclohexyl-meth-(E)-ylidene]-cyclopentane-1,3-dione (250 mg, 0.844 mmol) in methanol (25 ml) was added 10% palladium on carbon (50 mg, 20%) and stirred at room temperature under hydrogen balloon pressure for 7-8 hours. The reaction mixture was filtered through celite bed, concentrated under high vacuum. Compounds were separated by auto prep purification system to give 4-cyclohexylmethyl-2-(2,6-dimethyl-phenyl)-cyclopentane-1,3-dione.

Provenance & Evidence