HCID 66868360, compound → HCID 66867027, compound

Participants

Reaction Steps

A solution of 5-[1-Cyclopropyl-methylidene]-3-methoxy-2-(2,4,6-trimethyl-phenyl)-cyclopent-2-enone (83 mg, 0.28 mmol) in morpholine (3 ml) was heated at 10° C. for 17 hours. The reaction was allowed to cool to room temperature and then evaporated to dryness under reduced pressure. The crude material was dissolved in EtOAc (15 ml) and then washed with 2M HCl (3×15 ml) and brine (15 ml). The organic phase was dried over Na2SO4, filtered and evaporated to dryness under reduced pressure to give a colourless oil (200 mg). The crude material was purified by flash chromatography over SiO2 using a 100% hexane to 100% EtOAc gradient to give the desired compound as a white solid (45 mg).

Provenance & Evidence