HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → [3,5-Dimethyl-1-(4-nitro-benzyl)-1H-pyrazol-4-yl]-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Nitrobenzyl bromide | HCID 66011 | — |
| Reactant | methyl 2-(3,5-dimethyl-1H-pyrazol-4-yl)acetate | HCID 7131483 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | [3,5-Dimethyl-1-(4-nitro-benzyl)-1H-pyrazol-4-yl]-acetic acid methyl ester | HCID 66707610 | — |
Reaction Steps
To a solution of (3,5-dimethyl-1H-pyrazol-4-yl)-acetic acid methyl ester (3.90 g, 23 mmol, Enamine EN300-15247) and 4-nitrobenzyl bromide (4.60 g, 20.7 mmol) in acetonitrile was added K2CO3 (2.76 g, 19.9 mmol) and the mixture was stirred for one hour at room temperature. The reaction mixture was poured into water and extracted twice with ethyl acetate. The organic phase was dried over MgSO4 and evaporated under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791272B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-78d2e69778c04553ac302ccd7c0c6084 |
| Source note | uspto-grants-2014_07 |