(3,5-diethyl-1H-pyrazol-4-yl)-acetic acid tert-butyl ester → [3,5-Diethyl-1-(4-nitro-benzyl)-1H-pyrazol-4-yl]-acetic acid tert-butyl ester

HRID 1631904Notes

Reaction equation

HRID 1631904 reaction equation
COC(=O)CC1C(C)=NN([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][CH:13]=2)C=1C.[C:23]([O:27][C:28](=[O:39])[CH2:29][C:30]1[C:31]([CH2:37][CH3:38])=[N:32][NH:33][C:34]=1[CH2:35][CH3:36])([CH3:26])([CH3:25])[CH3:24]>>[C:23]([O:27][C:28](=[O:39])[CH2:29][C:30]1[C:34]([CH2:35][CH3:36])=[N:33][N:32]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][CH:13]=2)[C:31]=1[CH2:37][CH3:38])([CH3:25])([CH3:26])[CH3:24]

Participants

3

Reactant 2

HCID 66707366(3,5-diethyl-1H-pyrazol-4-yl)-acetic acid tert-butyl esterHCID 66707610[3,5-Dimethyl-1-(4-nitro-benzyl)-1H-pyrazol-4-yl]-acetic acid methyl ester

Product 1

HCID 66707489[3,5-Diethyl-1-(4-nitro-benzyl)-1H-pyrazol-4-yl]-acetic acid tert-butyl ester

Procedure

[3,5-Diethyl-1-(4-nitro-benzyl)-1H-pyrazol-4-yl]-acetic acid tert-butyl ester was prepared according to the preparation of intermediate 1.1.2, using in the alkylation reaction (3,5-diethyl-1H-pyrazol-4-yl)-acetic acid tert-butyl ester (preparation according to WO2007/141267) instead of (3,5-dimethyl-1H-pyrazol-4-yl)-acetic acid methyl ester.

Sources & evidence

ORD record
ord-885adac7f7df4bfcb8e92879c34b76d4
Source dataset
uspto-grants-2014_07
Patent number
US08791272B2

Reaction notes

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