HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Cyclohexylbutane-1,3-dione → [3-Cyclohexyl-5-methyl-1-(4-nitro-benzyl)-1H-pyrazol-4-yl]-acetic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Cyclohexylbutane-1,3-dione | HCID 162099 | — |
| Reactant | methyl 2-(3,5-dimethyl-1H-pyrazol-4-yl)acetate | HCID 7131483 | — |
| Reactant | (3,5-diethyl-1H-pyrazol-4-yl)-acetic acid tert-butyl ester | HCID 66707366 | — |
| Reactant | (3-cyclohexyl-5-methyl-1H-pyrazol-4-yl)-acetic acid tert-butyl ester | HCID 66707369 | — |
| Reactant | [3,5-Dimethyl-1-(4-nitro-benzyl)-1H-pyrazol-4-yl]-acetic acid methyl ester | HCID 66707610 | — |
| Product | [3-Cyclohexyl-5-methyl-1-(4-nitro-benzyl)-1H-pyrazol-4-yl]-acetic acid tert-butyl ester | HCID 66707492 | — |
Reaction Steps
[3-Cyclohexyl-5-methyl-1-(4-nitro-benzyl)-1H-pyrazol-4-yl]-acetic acid tert-butyl ester was prepared according to the preparation of intermediate 1.1.2, using in the alkylation reaction (3-cyclohexyl-5-methyl-1H-pyrazol-4-yl)-acetic acid tert-butyl ester (preparation according to the preparation of (3,5-diethyl-1H-pyrazol-4-yl)-acetic acid tert-butyl ester, WO2007/141267, employing 1-cyclohexyl-butane-1,3-dione instead of heptane-3,5-dione) instead of (3,5-dimethyl-1H-pyrazol-4-yl)-acetic acid methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791272B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-076969497d65413cab5b2714201e934b |
| Source note | uspto-grants-2014_07 |