Carbamate → HCID 58071782, compound

HRID 1631910Notes

Reaction equation

HRID 1631910 reaction equation
C([O:5][C:6](=[O:25])[CH2:7][C:8]1[C:9]([CH2:23][CH3:24])=[N:10][N:11]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=2)[C:12]=1[CH2:13][CH3:14])(C)(C)C.[C:26](=[O:29])([O-:28])N>>[CH2:15]([O:28][C:26]([NH:22][C:19]1[CH:18]=[CH:17][C:16]([CH2:15][N:11]2[C:12]([CH2:13][CH3:14])=[C:8]([CH2:7][C:6]([OH:5])=[O:25])[C:9]([CH2:23][CH3:24])=[N:10]2)=[CH:21][CH:20]=1)=[O:29])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 276CarbamateHCID 66707286HCID 66707286, compound

Product 1

HCID 58071782HCID 58071782, compound

Procedure

Example 3.3 was prepared according to the method described for method 3.1, employing intermediate 2.1.2 instead of intermediate 1.1.3 in the carbamate formation step. The subsequent cleavage of the tert-butyl ester was performed under acidic conditions as described for example 2.1.

Workup

  1. customExample 3.3 was prepared

Sources & evidence

ORD record
ord-078b20d745c0412dbdc1f2fd8b104d83
Source dataset
uspto-grants-2014_07
Patent number
US08791272B2

Reaction notes

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