HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → N-{4-[(3,5-Dimethyl-4-{[(2-methylpropane-2-sulfonyl)carbamoyl]methyl}-1H-pyrazol-1-yl)methyl]phenyl}-4-(trifluoromethyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | tert-Butylsulfonamide | HCID 2757335 | — |
| Reactant | {3,5-Dimethyl-1-[4-(4-trifluoromethyl-benzoylamino)-benzyl]-1H-pyrazol-4-yl}-acetic acid | HCID 58071835 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-{4-[(3,5-Dimethyl-4-{[(2-methylpropane-2-sulfonyl)carbamoyl]methyl}-1H-pyrazol-1-yl)methyl]phenyl}-4-(trifluoromethyl)benzamide | HCID 58071686 | — |
Reaction Steps
{3,5-Dimethyl-1-[4-(4-trifluoromethyl-benzoylamino)-benzyl]-1H-pyrazol-4-yl}-acetic acid (example 1.1, 250 mg, 0.58 mmol), 2-methylpropane-2-sulfonamide (95 mg, 0.70 mmol), 1,3-dicyclohexylcarbodiimid (143 mg, 0.70 mmol) and 4-dimethylaminopyridine (85 mg, 0.70 mmol) in 2.5 ml dichloromethane were stirred for 3 h at 30° C. The solvent was removed under reduced pressure and the residue was purified by MPLC (silica gel, CH2Cl2/methanol 95:5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791272B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-a97462f9289c44bbad1ac07bee032a45 |
| Source note | uspto-grants-2014_07 |