HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → [1-(4-Formyl-benzyl)-3,5-dimethyl-1H-pyrazol-4-yl]-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | methyl 2-(3,5-dimethyl-1H-pyrazol-4-yl)acetate | HCID 7131483 | — |
| Reactant | 4-(Bromomethyl)benzaldehyde | HCID 11206421 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | [1-(4-Formyl-benzyl)-3,5-dimethyl-1H-pyrazol-4-yl]-acetic acid methyl ester | HCID 86661579 | — |
Reaction Steps
(3,5-Dimethyl-1H-pyrazol-4-yl)-acetic acid methyl ester (1 g, 6.0 mmol), 4-(bromomethyl)-benzaldehyde (1.18 g, 6.0 mmol) and K2CO3 (1.73 g, 12.5 mmol) were refluxed in 5 ml acetonitrile for 12 h. After cooling, the mixture was filtered, and the solvent was removed under reduced pressure. The residue was purified by MPLC (silica gel, CH2Cl2/methanol 99:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791272B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-49a64262cafc40d4adafe6e518fb7707 |
| Source note | uspto-grants-2014_07 |