Hydrochloric Acid → {1-[4-(1-Hydroxy-2-phenyl-ethyl)-benzyl]-3,5-dimethyl-1H-pyrazol-4-yl}-acetic acid

https://huagongshe.com/reaction/1631924

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	Water	HCID 962	—
Reactant	Sodium Hydroxide	HCID 14798	—
Reactant	{1-[4-(1-Hydroxy-2-phenyl-ethyl)-benzyl]-3,5-dimethyl-1H-pyrazol-4-yl}-acetic acid methyl ester	HCID 66707459	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	{1-[4-(1-Hydroxy-2-phenyl-ethyl)-benzyl]-3,5-dimethyl-1H-pyrazol-4-yl}-acetic acid	HCID 58071843	—

Reaction Conditions

Temperature	60 °C

Reaction Steps

{1-[4-(1-Hydroxy-2-phenyl-ethyl)-benzyl]-3,5-dimethyl-1H-pyrazol-4-yl}-acetic acid methyl ester (intermediate 15.1.2, 110 mg, 0.29 mmol) was dissolved in 3 ml dioxane and aqueous NaOH solution (0.58 ml, 1 M) was added. After stirring for 2.5 h at 60° C. and dilution with water, aqueous HCl solution (0.61 ml, 1 M) was added. The mixture was extracted with ethyl acetate, and the organic layer was dried with MgSO4 and evaporated under reduced pressure. The residue was lyophilized.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08791272B2
Source dataset	uspto-grants-2014_07
ORD ID	ord-c4364199ed5d4700911ce6e25e18b6df
Source note	uspto-grants-2014_07