HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → [1-(4-Hydroxymethyl-benzyl)-3,5-dimethyl-1H-pyrazol-4-yl]-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | [4-(Chloromethyl)phenyl]methanol | HCID 5107660 | — |
| Reactant | methyl 2-(3,5-dimethyl-1H-pyrazol-4-yl)acetate | HCID 7131483 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | [1-(4-Hydroxymethyl-benzyl)-3,5-dimethyl-1H-pyrazol-4-yl]-acetic acid methyl ester | HCID 66707588 | — |
Reaction Steps
(3,5-dimethyl-1H-pyrazol-4-yl)-acetic acid methyl ester (3 g, 18 mmol), 4-(chloromethyl)benzyl alcohol (3.59 g, 18 mmol) and K2CO3 (5.18 g, 37 mmol) were refluxed in 10 ml acetonitrile for 3 h. After cooling, the mixture was filtered, and the solvent was removed under reduced pressure. The residue was purified by MPLC (silica gel, CH2Cl2/methanol 9:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791272B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-200498e28d9b432aa5e0605798e83dee |
| Source note | uspto-grants-2014_07 |