HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 3-tert-butoxycarbonylmethyl-5-chloro-2-oxo-2,3-dihydrobenzimidazole-1-carboxylate → tert-Butyl (6-chloro-2-oxo-2,3-dihydrobenzimidazol-1-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 3-tert-butoxycarbonylmethyl-5-chloro-2-oxo-2,3-dihydrobenzimidazole-1-carboxylate | HCID 66754580 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | tert-Butyl (6-chloro-2-oxo-2,3-dihydrobenzimidazol-1-yl)acetate | HCID 86642492 | — |
Reaction Steps
A solution of 1.8 g (4.70 mmol) of tert-butyl 3-tert-butoxycarbonylmethyl-5-chloro-2-oxo-2,3-dihydrobenzimidazole-1-carboxylate (VIIg) in 100 ml of 2% trifluoroacetic acid in dichloromethane was stirred at room temperature for 16 h. The solvent was removed in vacuo and the residue was dried in vacuo. Yield: 1.32 g (100%) of colorless solid
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791148B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-ae7d5fb9daf04e8fbedcbe62608cad8c |
| Source note | uspto-grants-2014_07 |