Trifluoroacetic acid → (6-Iodo-2-oxo-2,3-dihydrobenzimidazol-1-yl)acetic acid

Participants

Reaction Steps

2.10 g (4.43 mmol) of tert-butyl 3-tert-butoxycarbonylmethyl-5-iodo-2-oxo-2,3-dihydrobenzimidazole-1-carboxylate (VIIj) were dissolved in dichloromethane (50 ml) and, while stirring at room temperature, trifluoroacetic acid (25 ml) was added. The reaction solution was stirred for 2 h and then the solvent and excess trifluoroacetic acid were removed in vacuo. The residue was taken up again in toluene, concentrated in vacuo and then dried in vacuo. Yield: 1.39 g (99%) of white solid.

Provenance & Evidence