HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 57703728, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Iodo-3-nitrobenzene | HCID 12574 | — |
| Reactant | (2-Methoxy-5-methylphenyl)boronic acid | HCID 2773485 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 57703728 | HCID 57703728 | — |
Reaction Steps
A reaction mixture of 2-methoxy-5-methylphenyl boronic acid (1.65 g, 10 mmol), 3-nitro-iodobenzen (2.49 g, 10 mmol), K2CO3 (2.76 g, 20 mmol), palladium(II)acetate (112 mg, 0.5 mmol) in methanol (75 ml) and water (15 ml) was stirred at rt overnight. The reaction mixture was diluted with ethyl acetate (300 ml) washed with diluted Na2S2O7 aq., water, brine, and dried over Na2SO4. After removal of solvent, 2.5 g (100%) of I-69 was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791267B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-64d67b393c9944bfab09e03def141695 |
| Source note | uspto-grants-2014_07 |