Triethylsilane → 2-Bromo-6-[(4-fluorophenyl)methyl]-3-methoxybenzonitrile

Participants

Reaction Steps

To a solution of I-123 (0.15 g, 0.45 mmol) in trifluoroacetic acid (1.0 mL) was added triethylsilane (0.55 g, 4.5 mmol). The reaction mixture was stirred at room temperature for 20 h, then concentrated under vacuum to afford I-124 (0.14 g, 94% yield) as white solid.

Provenance & Evidence