Imidazole → HCID 131731720, compound

Participants

Reaction Steps

A solution of (S)-5-hydroxymethyl-pyrrolidin-2-one (1.0 g, 8.69 mmol), DMF (10 mL), t-butyldimethylsilyl chloride (1.57 g, 10.42 mmol), and imidazole (0.89 g, 13.03 mmol) was stirred at ambient temperature for 4 hours after which time 4 mL of water were added. The layers were separated and the aqueous was extracted with dichloromethane (10 mL). The combined organics were washed with water (15 mL) and brine (15 mL), dried with sodium sulfate, filtered and concentrated to afford 1.91 g of I-188 as a colorless oil in 96% yield.

Provenance & Evidence