(R)-(+)-4-Hydroxy-2-pyrrolidinone → HCID 58020049, compound

Participants

Reaction Steps

P-506 was prepared in a similar manner as that described above for P-248 except starting with (R)-4-Hydroxy-pyrrolidin-2-one. 1H NMR (400 MHz, CDCl3) 8.40 (t, J=1.9 Hz, 1H), 8.17 (dd, J=1.7, 8.2 Hz, 1H), 7.84 (d, J=7.8 Hz, 1H), 7.55 (t, J=8.0 Hz, 1H), 7.30-7.27 (m, 1H), 7.22 (d, J=2.1 Hz, 1H), 6.97 (d, J=8.5 Hz, 1H), 4.61-4.48 (m, 2H), 4.41 (d, J=14.8 Hz, 1H), 3.85-3.81 (m, 3H), 3.56 (dd, J=5.6, 10.9 Hz, 1H), 3.24 (dd, J=1.8, 10.8 Hz, 1H), 2.75 (dd, J=6.5, 17.3 Hz, 1H), 2.44 (dd, J=2.1, 17.4 Hz, 1H), 2.12 (br s, 1H) ppm. LC/MS=95.6%, 343.1 (APCI+).

Provenance & Evidence