Methyl Isocyanate → 1-Methyl-3-(5-(1-(methoxymethyl)-1-methylethyl)-1,2-oxazol-3-yl)urea

HRID 1632119Notes

Reaction equation

HRID 1632119 reaction equation
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]([CH2:10][O:11][CH3:12])([CH3:9])[CH3:8])[O:4][N:3]=1.[CH3:13][N:14]=[C:15]=[O:16]>CCOCC>[CH3:13][NH:14][C:15]([NH:1][C:2]1[CH:6]=[C:5]([C:7]([CH3:9])([CH3:8])[CH2:10][O:11][CH3:12])[O:4][N:3]=1)=[O:16]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 133396145-(1-Methoxy-2-methylpropan-2-yl)-1,2-oxazol-3-amine

Product 1

HCID 133396151-Methyl-3-(5-(1-(methoxymethyl)-1-methylethyl)-1,2-oxazol-3-yl)urea

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of 1.0 g of 3C and 1.0 g of methyl isocyanate in 15 ml of anhydrous ether was held at room temperature for 3 days. Then the solvent was evaporated and the residue was crystallized from hexane to give 1-methyl-3-(5-(1,1-dimethyl-2-methoxyethyl)-1,2-oxazol-3-yl)urea (3D), as a colorless solid, m.p.: 113°-115° C.

Workup

  1. customThen the solvent was evaporated
  2. customthe residue was crystallized from hexane

Sources & evidence

ORD record
ord-b45902638b2f4670bb493eb257d42021
Source dataset
uspto-grants-1984_10
Patent number
US04474598

Reaction notes

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