Hydrochloric Acid → HCID 131713829, compound

Participants

Reaction Steps

Boc-Aib-Phe-Leu-OMe (14.38 g.) was dissolved in ethyl acetate (25 ml.). A solution of 3M-hydrogen chloride in ethyl acetate (33 ml.) was added and the mixture was stirred at ambient temperature for 1 hr., during which time a white crystalline solid separated out. The solid was collected by filtration, washed with ethyl acetate (3×15 ml.) and then dried in vacuo at ambient temperature to give H-Aib-Phe-Leu-OMe hydrochloride, RfKNH3 0.89, RfRNH3 0.74.

Provenance & Evidence