Pyridine → HCID 20443844, compound

HRID 1632181Notes

Reaction equation

HRID 1632181 reaction equation
[NH2:1][C:2]1[C:7](=[O:8])[NH:6][C:5]2[O:9][CH2:10][C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[C:4]=2[CH:3]=1.N1C=CC=CC=1.[C:23](Cl)(=[O:25])[CH3:24]>C(Cl)(Cl)Cl>[C:23]([NH:1][C:2]1[C:7](=[O:8])[NH:6][C:5]2[O:9][CH2:10][C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[C:4]=2[CH:3]=1)(=[O:25])[CH3:24]

Participants

5

Reactant 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 20443821HCID 20443821, compound

Product 1

HCID 20443844HCID 20443844, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To 2.0 gm of 2-amino-4,6-dihydro-3H-[2]benzopyrano[3,4-b]pyridin-3-one, in 100 ml of chloroform containing 1 ml of pyridine, add 0.80 gm of acetyl chloride. Stir the reaction at room temperature for 5 hours. Filter and wash the solution with water. Remove the solvent by stripping to give the title compound.

Workup

  1. customthe reaction at room temperature for 5 hours
  2. filtrationFilter
  3. washwash the solution with water
  4. customRemove the solvent

Sources & evidence

ORD record
ord-c560aceb02494dd1a54854379911e81f
Source dataset
uspto-grants-1984_10
Patent number
US04474786

Reaction notes

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