Sulfuric Acid → HCID 20443853, compound

HRID 1632182Notes

Reaction equation

HRID 1632182 reaction equation
S(=O)(=O)(O)O.[CH:6]1[C:7]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[CH2:17][O:16][C:8]=2[NH:9][C:10](=[O:15])[C:11]=1C(O)=O.[OH-].[Na+]>O>[CH:6]1[C:7]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[CH2:17][O:16][C:8]=2[NH:9][C:10](=[O:15])[CH:11]=1

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 20443817HCID 20443817, compound

Product 1

HCID 20443853HCID 20443853, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture of 60 ml of concentrated sulfuric acid and 15 ml of water, add 22.2 gm of 4,6-dihydro-3H[2]benzopyrano-[3,4-b]pyridin-3-one-2-carboxylic acid. Heat the system at reflux for 24 hours. Cool the system and pour the solution into 1 liter of ice/water. Neutralize the solution with 10N NaOH solution. Extract the solution with 300 ml of chloroform and dry the organic solution over anhydrous magnesium sulfate. Filter the solution and remove the solvent by stripping to give 4,6-dihydro-3H[2]-benzopyrano-[3,4-b]pyridin-3-one.

Workup

  1. temperatureHeat the system
  2. temperatureat reflux for 24 hours
  3. temperatureCool the system
  4. extractionExtract the solution with 300 ml of chloroform
  5. dry with materialdry the organic solution over anhydrous magnesium sulfate
  6. filtrationFilter the solution
  7. customremove the solvent

Sources & evidence

ORD record
ord-4cb95111ef7b4f249d48192044619cb5
Source dataset
uspto-grants-1984_10
Patent number
US04474786

Reaction notes

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