HCID 13770487, compound → HCID 13770488, compound

HRID 1632205Notes

Reaction equation

HRID 1632205 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]2[CH:13]=[C:14]([CH2:16][OH:17])[CH:15]=[C:5]2[C:4]1=[O:18])[CH3:2]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]2[CH:13]=[C:14]([CH:16]=[O:17])[CH:15]=[C:5]2[C:4]1=[O:18])[CH3:2]

Participants

4

Reactant 1

HCID 13770487HCID 13770487, compound

Product 1

HCID 13770488HCID 13770488, compoundYield 80%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Procedure

A mixture of 40 g of activated manganese dioxide and a solution of 5.0 g (20.6 mmole) of the product of Example 24 in 500 ml of chloroform was vigorously stirred for 3 hours and was then filtered through celite. The filtrate was evaporated to dryness and the residue was triturated with ether to obtain 3.9 g (80% yield) of 4,5-dihydro-5-ethyl-4-oxopyrrolo-[1,2-a]-quinoxaline-2-carboxaldehyde in the form of colorless needles melting at 252°-255° C.

Workup

  1. filtrationwas then filtered through celite
  2. customThe filtrate was evaporated to dryness
  3. customthe residue was triturated with ether

Sources & evidence

ORD record
ord-e8decabaa2644d1e917508f9a7f8ee0f
Source dataset
uspto-grants-1984_10
Patent number
US04474784

Reaction notes

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