反应详情

To a solution of phenyllithium in 150 milliliters 7:3 benzene-ether (0.1 mole) at 0° C. was slowly added a solution of 13.6 grams of tetramethylpyrazine (0.1 mole). The mixture was stirred at room temperature for 2 hours and heated under reflux for 1.5 hours. The mixture was cooled to 0° C., and a solution of 12.0 grams of p-tolualdehyde (0.1 mole) in 50 milliliters of ether was added dropwise. The reaction mixture was stirred at room temperature for 1 hour and then treated in the manner of Example I. The crude product was crystallized from ether to yield 10.7 grams of product (42%) as fine white needles, m.p. 99°-101° C. Analysis Calculated for C16H20N2O: C,74.96; H,7.86; N,10.93 Found: 75.19; 7.96; 10.88

1. temperatureheated
2. temperatureunder reflux for 1.5 hours
3. temperatureThe mixture was cooled to 0° C.
4. stirringThe reaction mixture was stirred at room temperature for 1 hour
5. additiontreated in the manner of Example I
6. customThe crude product was crystallized from ether