Dichloromethane → Benzyl glycidyl ether

Temperature

5 °C

A 2,000 mL, 3-necked flask equipped with a mechanical stirrer and thermometer was charged with 3-benzyloxy-2-hydroxypropyl chloride (353 g, 1.76 mol) and dichloromethane (1,000 mL). This mixture was stirred and cooled in an ice bath to ca. 5° C. Aqueous 50% NaOH (176 g) was added in portions while the temperature was kept under 30° C. After addition was complete, the reaction mixture was stirred 4 hours at 25° C. Water (1,000 mL) was added to dissolve the salts. The organic phase was separated from the aqueous phase, washed with ice water (3×500 mL), dried and reduced in vacuo to yield 263 g (92%) of pure 3-benzyloxy-1,2-epoxypropane.

1. customA 2,000 mL, 3-necked flask equipped with a mechanical stirrer
2. customwas kept under 30° C
3. additionAfter addition
4. stirringthe reaction mixture was stirred 4 hours at 25° C
5. dissolutionto dissolve the salts
6. customThe organic phase was separated from the aqueous phase
7. washwashed with ice water (3×500 mL)
8. customdried

ORD record

ord-b64245fcfb8b46cab11d072a345906ab

Source dataset

uspto-grants-1984_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04474963