Phenol → Benzene, (2-bromoethoxy)-

In a mixed solution consisting of 50 g of 1,2-dibromoethane, 18.5 g of phenol and 100 ml of water was added dropwise 30 ml of water containing therein 7.9 g of sodium hydroxide at a temperature of 130° C. over 30 minutes with stirring. The reaction solution was further stirred for 6 hours. After completion of the reaction, the organic layer was separated from the reaction solution, washed twice with a saturated aqueous potassium carbonate solution, washed twice with water and dried with anhydrous sodium sulfate. The organic layer was separated by filtration and condensed under reduced pressure to give 34.3 g of 2-phenoxyethyl bromide having a boiling point of 105° C. to 107° C. at 6 mmHg in a yield of 85%.

1. customAfter completion of the reaction
2. customthe organic layer was separated from the reaction solution
3. washwashed twice with a saturated aqueous potassium carbonate solution
4. washwashed twice with water
5. dry with materialdried with anhydrous sodium sulfate
6. customThe organic layer was separated by filtration and condensed under reduced pressure

ORD record

ord-1b04852441f54c06afe85bb271407c49

Source dataset

uspto-grants-1984_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04474964