HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → HCID 70512849, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | 2-(Octylamino)-1-{4-[(propan-2-yl)sulfanyl]phenyl}propan-1-ol--hydrogen chloride (1/1) | HCID 3016912 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | HCID 70512849 | HCID 70512849 | — |
Reaction Steps
To 15 gr (40 mol) of 1-(4-isopropylthiophenyl)-2-n-octylamino-1-propanol hydrochloride, 12,6 gr (160 mmol) of acetyl chloride are added. Heating is provided for 1 hour at reflux temperature, then 30 ml of benzene are added, reflux being maintained for two further hours. When cooling, the resulting solution abandons a white solid. The latter is filtered, then recrystallised from benzene. The product then weighs 11.5 gr (28 mmol, 70%) and melt at 167.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04474977 |
| Source dataset | uspto-grants-1984_10 |
| ORD ID | ord-7c4e8b3f302e4802a39949c6e76981b6 |
| Source note | uspto-grants-1984_10 |