Hydrochloric Acid → Benzaldehyde

Participants

Reaction Steps

Propafenone (2'-(2-hydroxy-3-propylaminopropoxy)-3-phenylpropiophenone hydrochloride, German Pat. No. 2,001,431) is a substance having an anti-arrhythmic action. According to the said German patent, it is obtained by reacting 2-hydroxy-omega-phenylpropiophenone (as the sodium salt) with 1-chloro-2,3-epoxypropane and then reacting the resulting 2-(2',3'-epoxypropyl)-omega-phenylpropiophenone with n-propylamine and converting the product to the hydrochloride. This process gives a yield of only about 66%. Moreover, the starting material (2-hydroxy-omega-phenylpropiophenone) required for the reaction can only be obtained with difficulty from 2-hydroxyacetophenone by condensing with benzaldehyde and then hydrogenating the reaction product.

Provenance & Evidence