反应详情

To a solution of 4.80 g of Z-Ala-OSu in 60 ml of tetrahydrofuran was added a solution of 2.19 g of H-Gln-OH in 40 ml of water and 2.10 ml of triethylamine and the mixture was stirred at a room temperature for 20 hours. Tetrahydrofuran and water were removed by distillation and the residue thus obtained was extracted with n-butanol. The n-butanol extract was washed with a 2%-acetic acid and butanol was removed by distillation. The precipitated substance thus obtained was collected by filtration and reprecipitated with methanol-ethyl acetate to obtain 3.87 g of Z-Ala-Gln-OH.

1. customTetrahydrofuran and water were removed by distillation
2. customthe residue thus obtained
3. extractionwas extracted with n-butanol
4. extractionThe n-butanol extract
5. washwas washed with a 2%-acetic acid and butanol
6. customwas removed by distillation
7. customThe precipitated substance thus obtained
8. filtrationwas collected by filtration
9. customreprecipitated with methanol-ethyl acetate