HRID1632390

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

结构：CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)ON1C(=O)CCC1=O

HCID11089751

未命名化合物

结构：CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)O

HCID131713840

未命名化合物

PRODUCTS

生成物

结构：CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)O

HCID131713841

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

0.69 Gram of Z-Leu-OSu, the above-obtained H-Ile-Leu-Leu-Ala-Gln-OH and 0.22 ml of triethylamine were dissolved in 50 ml of dimethylformamide, and the mixture was stirred at a room temperature for 20 hours. After removal of dimethylformamide by distillation, 1N-succinic acid was added to the residue, the precipitated material was collected by filtration and washed with water until the filtrate become neutral and then dried. The dried material was washed with hot methanol to obtain 1.10 g of Z-Leu-Ile-Leu-Leu-Ala-Gln-OH.

WORKUP

后处理

customAfter removal of dimethylformamide
distillationby distillation, 1N-succinic acid
additionwas added to the residue
filtrationthe precipitated material was collected by filtration
washwashed with water until the filtrate
customdried
washThe dried material was washed with hot methanol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-94b1f016736a46f2b9bddeabdbb81f28
来源数据集: uspto-grants-1984_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04474754
来源说明: uspto-grants-1984_10

反应 SMILES

[NH:1]([C:17]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18])[C@H:2]([C:7]([O:9]N1C(=O)CCC1=O)=O)[CH2:3][CH:4]([CH3:6])[CH3:5].[NH2:27][C@H:28]([C:33]([NH:35][C@H:36]([C:41]([NH:43][C@H:44]([C:49]([NH:51][C@H:52]([C:54]([NH:56][C@H:57]([C:63]([OH:65])=[O:64])[CH2:58][CH2:59][C:60](=[O:62])[NH2:61])=[O:55])[CH3:53])=[O:50])[CH2:45][CH:46]([CH3:48])[CH3:47])=[O:42])[CH2:37][CH:38]([CH3:40])[CH3:39])=[O:34])[C@H:29]([CH2:31][CH3:32])[CH3:30].C(N(CC)CC)C>CN(C)C=O>[NH:1]([C:17]([O:19][CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:18])[C@H:2]([C:7]([NH:27][C@H:28]([C:33]([NH:35][C@H:36]([C:41]([NH:43][C@H:44]([C:49]([NH:51][C@H:52]([C:54]([NH:56][C@H:57]([C:63]([OH:65])=[O:64])[CH2:58][CH2:59][C:60](=[O:62])[NH2:61])=[O:55])[CH3:53])=[O:50])[CH2:45][CH:46]([CH3:47])[CH3:48])=[O:42])[CH2:37][CH:38]([CH3:40])[CH3:39])=[O:34])[C@H:29]([CH2:31][CH3:32])[CH3:30])=[O:9])[CH2:3][CH:4]([CH3:5])[CH3:6]