Acetic Acid → H-Leu-Ile-Leu-Leu-Ala-Gln-OH

HRID 1632391Notes

Reaction equation

HRID 1632391 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:7]([NH:9][C@H:10]([C:15]([NH:17][C@H:18]([C:23]([NH:25][C@H:26]([C:31]([NH:33][C@H:34]([C:36]([NH:38][C@H:39]([C:45]([OH:47])=[O:46])[CH2:40][CH2:41][C:42](=[O:44])[NH2:43])=[O:37])[CH3:35])=[O:32])[CH2:27][CH:28]([CH3:30])[CH3:29])=[O:24])[CH2:19][CH:20]([CH3:22])[CH3:21])=[O:16])[C@H:11]([CH2:13][CH3:14])[CH3:12])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].C(O)(=O)C>CO.[Pd]>[NH2:1][C@H:2]([C:7]([NH:9][C@H:10]([C:15]([NH:17][C@H:18]([C:23]([NH:25][C@H:26]([C:31]([NH:33][C@H:34]([C:36]([NH:38][C@H:39]([C:45]([OH:47])=[O:46])[CH2:40][CH2:41][C:42](=[O:44])[NH2:43])=[O:37])[CH3:35])=[O:32])[CH2:27][CH:28]([CH3:29])[CH3:30])=[O:24])[CH2:19][CH:20]([CH3:21])[CH3:22])=[O:16])[C@H:11]([CH2:13][CH3:14])[CH3:12])=[O:8])[CH2:3][CH:4]([CH3:5])[CH3:6]

Participants

5

Reactant 2

HCID 176Acetic AcidHCID 131713841Z-Leu-Ile-Leu-Leu-Ala-Gln-OH

Product 1

HCID 131713842H-Leu-Ile-Leu-Leu-Ala-Gln-OH

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

0.50 Gram of Z-Leu-Ile-Leu-Leu-Ala-Gln-OH was dissolved in 50 ml of methanol and 10 ml of 10%-acetic acid, and the mixture was catalytically reduced by using palladium as a catalyst to obtain H-Leu-Ile-Leu-Leu-Ala-Gln-OH. Hereinafter, this product is referred to as [Peptide A].

Sources & evidence

ORD record
ord-136aa19ef49644d6ba788cee47b75ab5
Source dataset
uspto-grants-1984_10
Patent number
US04474754

Reaction notes

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