HRID1632410

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID176

Acetic Acid

C2H4O2

反应SMILES：Cc1ccc(S(=O)(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)OCc2ccccc2)C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1

HCID178427448

未命名化合物

PRODUCTS

产物

反应SMILES：Cc1ccc(S(=O)(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1

HCID178427449

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

1.84 Grams of Z-Ser-Leu-Arg-Ser-Lys(Tos)-Glu-OH was suspended in a mixture of 30 ml of methanol with 30 ml of 10%-acetic acid, and a small amount of palladium black was added to the suspension and stirred for 13 hours under introducing hydrogen gas. After the reaction was completed, the catalyst was removed by suction filtration to obtain the filtrate. Then filtrate was distilled under a reduced pressure and the thus obtained residue was pured into water and then lyophilized to obtain the desired product.

WORKUP

后处理

customthe catalyst was removed by suction filtration
customto obtain the filtrate
distillationThen filtrate was distilled under a reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-1abc148c765e4c3cb903682b7b0f1206
来源数据集: uspto-grants-1984_10
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US04474754
来源说明: uspto-grants-1984_10

反应SMILES

[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:5]([NH:7][C@H:8]([C:13]([NH:15][C@H:16]([C:24]([NH:26][C@H:27]([C:30]([NH:32][C@H:33]([C:49]([NH:51][C@H:52]([C:58]([OH:60])=[O:59])[CH2:53][CH2:54][C:55](=[O:57])[OH:56])=[O:50])[CH2:34][CH2:35][CH2:36][CH2:37][NH:38][S:39]([C:42]1[CH:48]=[CH:47][C:45]([CH3:46])=[CH:44][CH:43]=1)(=[O:41])=[O:40])=[O:31])[CH2:28][OH:29])=[O:25])[CH2:17][CH2:18][CH2:19][NH:20][C:21](=[NH:23])[NH2:22])=[O:14])[CH2:9][CH:10]([CH3:12])[CH3:11])=[O:6])[CH2:3][OH:4].C(O)(=O)C>CO.[Pd]>[NH2:1][C@H:2]([C:5]([NH:7][C@H:8]([C:13]([NH:15][C@H:16]([C:24]([NH:26][C@H:27]([C:30]([NH:32][C@H:33]([C:49]([NH:51][C@H:52]([C:58]([OH:60])=[O:59])[CH2:53][CH2:54][C:55](=[O:56])[OH:57])=[O:50])[CH2:34][CH2:35][CH2:36][CH2:37][NH:38][S:39]([C:42]1[CH:48]=[CH:47][C:45]([CH3:46])=[CH:44][CH:43]=1)(=[O:41])=[O:40])=[O:31])[CH2:28][OH:29])=[O:25])[CH2:17][CH2:18][CH2:19][NH:20][C:21](=[NH:22])[NH2:23])=[O:14])[CH2:9][CH:10]([CH3:11])[CH3:12])=[O:6])[CH2:3][OH:4]