HCID 101282742, compound → Hydrazinecarboxylic acid, 2-(2,5-diamino-1,5-dioxopentyl)-, 1,1-dimethylethyl ester, (S)-

HRID 1632412Notes

Reaction equation

HRID 1632412 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:8]([NH:10][NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6].[H][H]>CO.[Pd]>[NH2:1][C@H:2]([C:8]([NH:10][NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6]

Participants

5

Reactant 2

HCID 101282742HCID 101282742, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 131713848Hydrazinecarboxylic acid, 2-(2,5-diamino-1,5-dioxopentyl)-, 1,1-dimethylethyl ester, (S)-

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

16.00 Grams of Z-Gln-NHNHBoc was suspended in 100 ml of methanol, a small amount of palladium black was added thereto and stirred for 18 hours under the condition of introducing hydrogen gas. After completion of the reaction, the catalyst was removed by suction filtration, the filtrate was subjected to distillation under a reduced pressure, the residue thus obtained was dried under a reduced pressure in a desiccator to obtain the desired product.

Workup

  1. customAfter completion of the reaction
  2. customthe catalyst was removed by suction filtration
  3. distillationthe filtrate was subjected to distillation under a reduced pressure
  4. customthe residue thus obtained
  5. customwas dried under a reduced pressure in a desiccator

Sources & evidence

ORD record
ord-44479dbde1ce42ad8d84a28f03963681
Source dataset
uspto-grants-1984_10
Patent number
US04474754

Reaction notes

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