2-Amino-2',5-dichlorobenzophenone → 2-bromo-N-(4-chloro-2-(2-chlorobenzoyl)phenyl)acetamide

Participants

Reaction Steps

To an iced solution of 266 g (1 mol) of 2-amino-2',5-dichlorobenzophenone in 3 liters of ethyl ether there are added, drop by drop, 90 cc (1.1 mol) of bromoacetyl chloride dissolved in 500 cc of ethyl ether. The batch is allowed to come to room temperature, whereupon it is evaporated to dryness and the crystalline residue extracted with petroleum ether and filtered. In this manner, 371 g of crystals are recovered.

Provenance & Evidence