Triphenylphosphine → HCID 20442920, compound

Participants

Reaction Steps

The crude (4-trifluoromethoxy-2,3,6-trimethylphenyl)methyl chloride, 27.5 g (0.104 mol) of triphenylphosphine and 250 ml of acetonitrile were heated to reflux for 20 hours. The solvent was removed on a rotary evaporator at room temperature and the residue was triturated with 300 ml of ethyl acetate. The resulting solid was filtered, dissolved in 250 ml of hot acetonitrile and treated with 1 liter of ethyl acetate. The mixture was allowed to stand 2 hours; 38 g of (4-trifluoromethoxy-2,3,6-trimethylphenyl)methyltriphenylphosphonium chloride was collected; mp 272°-274° C. In a similar manner, the mother liquor afforded an additional 10.5 g of product.

Provenance & Evidence