Sulfuric acid magnesium salt (1:1) → HCID 86739678, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl (2E,4E,6E,8E)-3,7-dimethyl-9-[2,3,6-trimethyl-4-(trifluoromethoxy)phenyl]-nonatetraenoate could be dissolved in methylene chloride and treated with diisobutylaluminum hydride in hexane solution at -60° C. under argon. The temperature is raised to -10° C. for 10 to 30 minutes and then a saturated solution of magnesium sulfate is added. The mixture is stirred at 25° C. for 2 hours, filtered and evaporated to give (2E,4E,6E,8E)-3,7-dimethyl-9-[2,3,6-trimethyl-4-(trifluoromethoxy)phenyl]-nonatetraen-1-ol which is further purified by conventional chromatography.

Provenance & Evidence