HCID 20442969, compound → HCID 20442970, compound

HRID 1632479Notes

Reaction equation

HRID 1632479 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N+:9]([O-])=O)[C:6]([O:12][CH3:13])=[CH:5][C:4]=1[N:14]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:15](=[O:21])[C:16]([O:18][CH2:19][CH3:20])=[O:17]>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([NH2:9])[C:6]([O:12][CH3:13])=[CH:5][C:4]=1[N:14]([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[C:15](=[O:21])[C:16]([O:18][CH2:19][CH3:20])=[O:17]

Participants

3

Reactant 1

HCID 20442969HCID 20442969, compound

Product 1

HCID 20442970HCID 20442970, compoundYield 94.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of the nitro compound of Example 2A (30 g) and 3.6 g of 5% pd/c in 600 ml of ethanol was hydrogenated at 40 psi overnight. The reaction mixture was filtered and the catalyst was washed well with methylene chloride. The organic solution was evaporated to dryness to give 26 g of the title compound. This was used for the next reaction without further purification.

Workup

  1. customwas hydrogenated at 40 psi overnight
  2. filtrationThe reaction mixture was filtered
  3. washthe catalyst was washed well with methylene chloride
  4. customThe organic solution was evaporated to dryness

Sources & evidence

ORD record
ord-0f1f9291498c49fd96cf7a3da5f42b68
Source dataset
uspto-grants-1984_10
Patent number
US04476125

Reaction notes

Loading…