2-Chloro-4'-fluoropropiophenone → HCID 86739682, compound

HRID 1632484Notes

Reaction equation

HRID 1632484 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:18]2C=CC(F)=C[CH:19]=2)[O:9]CCN2CCNCC2)=[CH:4][CH:3]=1.[Cl:25]CCC(C1C=CC(F)=CC=1)=O>>[ClH:25].[ClH:25].[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[O:9])[CH2:18][CH3:19])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 676722-Chloro-4'-fluoropropiophenoneHCID 99740131-[2-[Bis(4-fluorophenyl)methoxy]ethyl]piperazine

Product 1

HCID 86739682HCID 86739682, compound

Procedure

1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]piperazine and 3-chloro-1-(4-fluorophenyl)-1-propanone were reacted with each other as decribed in Example VI. After evaporation of the solvent, water and chloroform were added. The working up was further as in Example VI, except that the residue of the column fraction was taken up in ethanol. 3-[4-[2-bis(4-fluorophenyl)methoxy]ethyl]-1-piperazinyl)-1-(4-fluorophenyl)-1-propanone dihydrochloride was obtained.

Workup

  1. customAfter evaporation of the solvent, water and chloroform
  2. additionwere added

Sources & evidence

ORD record
ord-29a79c060aa14354bb3783eb0b68f5e2
Source dataset
uspto-grants-1984_10
Patent number
US04476129

Reaction notes

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