Chloroacetyl chloride → HCID 13068336, compound

HRID 1632493Notes

Reaction equation

HRID 1632493 reaction equation
[O:1]=[C:2]1[CH2:8][O:7][CH:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]([F:18])([F:17])[F:16])[C:5]2[CH:19]=[CH:20][CH:21]=[CH:22][C:4]=2[NH:3]1.[Cl:23]CC(Cl)=O>C1C=CC=CC=1>[Cl:23][CH2:8][C:2]([NH:3][C:4]1[CH:22]=[CH:21][CH:20]=[CH:19][C:5]=1[C:6]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]([F:18])([F:17])[F:16])=[O:7])=[O:1]

Participants

4

Reactant 2

HCID 6577Chloroacetyl chlorideHCID 13068341HCID 13068341, compound

Product 1

HCID 13068336HCID 13068336, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a solution of 2-amino-2'-trifluoromethylbenzophenone 1 [L. H. Sternbach et al. Helv. Chim. Acta., 45, 2226 (1962)] (8 g) in benzene (80 ml) is added chloroacetyl chloride (29 ml), and the mixture is refluxed under heating for 30 minutes. Benzene is evaporated under reduced pressure, and the residue is washed with n-hexane to give crystalline 2-(2-chloroacetyl)amino-2'-trifluoromethylbenzophenone (10.05 g), which is recrystallized from benzene-n-hexane to give the pure crystals, mp. 79°-81° C.

Workup

  1. temperaturethe mixture is refluxed
  2. temperatureunder heating for 30 minutes
  3. customBenzene is evaporated under reduced pressure
  4. washthe residue is washed with n-hexane

Sources & evidence

ORD record
ord-ce5f3e5edca24f7489b19c54307209ba
Source dataset
uspto-grants-1984_10
Patent number
US04476133

Reaction notes

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